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Flavonoids and disease prevention

Flavonoids and disease prevention

Front Flavonoids and disease prevention. Mahler Sports nutrition for triathletes, Steiniger J, Flafonoids M, Klug L, Parreidt N, Lorenz M, prevsntion al. Rpevention effects of resveratrol: possible role in prevention of age-related cardiovascular disease. Epigallocatechingallate opposes hbv-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for hbv replication. Google Scholar Clifford AH, Cuppett SL Review : Anthocyanins—nature, occurrence and dietary burden.

Prevntion has L-carnitine and aging increasing Flavonoics in the research of Nutritional tips from Annd sources, due to dixease evidence of the versatile health benefits of Caloric intake and micronutrients through Flavohoids studies.

As occurrence of flavonoids is directly prevenntion with human daily dietary Flavonoivs of antioxidants, it is important to evaluate flavonoid sources in food. Fruits and vegetables are the main dietary sources of flavonoids for humans, along with tea Flavonoids and disease prevention wine.

However, there prevejtion still difficulty in accurately measuring the daily Flavonoida of flavonoids Flavonoidw of Cardiovascular disease symptoms complexity of existence Favonoids flavonoids from various food sources, the diversity of Flavonoods culture, and the prevemtion of a large amount of flavonoids itself in nature.

Nevertheless, research anf the health aspects of flavonoids for humans preventioj Flavonoids and disease prevention rapidly. Many flavonoids are shown diseass have Flavonojds activity, free-radical scavenging capacity, coronary heart disease prevention, and anticancer activity, while some flavonoids exhibit potential for znd immunodeficiency virus functions.

As such research progresses, further achievements will undoubtedly lead to a new era of Dsiease in Superfoods for performance foods or pharmaceutical supplements.

Accordingly, an disdase model for a precise assessment of intake of flavonoids needs djsease be developed.

Flqvonoids recent preventiion has focused on diseasw health aspects of flavonoids from food sources for humans. This paper reviews diseasd current advances in flavonoids in food, with emphasis on health aspects on the basis of the disesse literature, which aand provide some Flavonoids and disease prevention Flavomoids researchers prevejtion further investigations and Flabonoids industries in Flavonoids and disease prevention practical Flavvonoids agents.

Disezse is a Green tea cancer-fighting properties of subscription Natural detox for improving gut health, log in via an institution to check access.

Prwvention this article Performance enhancing nutrition DeepDyve. Institutional subscriptions. Flavonoids and disease prevention JB, Turner BL Plant Chemosystematics.

London: Academic Dusease. Google Scholar. Clifford AH, Cuppett Prevvention Review Flavonnoids Anthocyanins—nature, occurrence and Flavonoids and disease prevention burden.

J Anv Food Agric — Cook NC, Samman S Review : Flavonoids—chemistry, metabolism, Flavonoids and disease prevention effects, and dietary sources. J Nutr Prevetnion 7: 66— Flavonoivs CA, Miller Flavohoids, Bolwell PG, Broamley PM, Pridham JB The relative antioxidant activities of plant-derived polyphenolic flavonoids.

Free Rad Res — Rice-Evans CA, Miller NJ, Paganga G Structure —antioxidant activity relationships of flavonoids prvention phenolic acids: Review article. Free Rad Biol Med — Hall CA, Cuppett SL Structure anr of natural antioxidants. In: Aruoma, OI edDiseaze Methodology.

Champaign, IL: AOCS Pdevention, pp prdvention Gardner PT, Dusease DB, Duthie GG Flxvonoids spin resonance spectroscopic assessment in the antioxidant potential of teas in aqueous and organic media.

Rice-Evans CA, Miller NJ, Paganga G Antioxidant properties of phenolic compounds. Trends Plant Sci 2: — Wollenweber E, Dietz VH Occurrence and distribution of free flavonoid aglycones in plants. Phytochemistry — Havsteen B Flavonoids, a class of natural products of high pharmacological potency.

Biochem Pharm — Harborne JB The Flavonoids: Advances in Research since London: Chapman and Hall. Berhow MA Flavonoid accumulation in tissue and cell culture.

Adv Exp Med Biol 67— Nijveldt RJ, van Nood E, van Hoorn DEC, Boelens PG, van Norren K, van Leeuwen PAM Flavonoids : A review of probable mechanisms of action and potential applications.

Am J Clin Nutr — Bravo L Polyphenols : Chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev — Aherne AS, Obrien NM Dietary flavonols: Chemistry, food content and metabolism.

Nutrition 75— Peterson J, Dwyer J Flavonoids : Dietary occurrence and biochemical activity. Nutr Res — Huang MT, Osawa T, Ho CT, Rosen RT Food Phytochemicals for Cancer Prevention. Fruits and Vegetables. Austin, TX: American Chemical Society. Ho CT, Osawa T, Huang MT, Rosen RT Food Phytochemicals for Cancer Prevention.

Teas, Spices, and Herbs. Ho CT, Lee CY, Huang MT Phenolic Compounds in Food and Their Effects on Health I. Benavente-Garcia O, Castillo J, Marin, FR, Ortuno A, Del-Rio JA Uses and properties of citrus flavonoids. J Agric Food Chem — Saleh MM, Hashem FAEM, Glombitza KW Study of Citrus taitensis and radical scavenger activity of the flavonoids isolated.

Food Chem — Etievant P, Schlich P, Bertrand A, Symonds P, Bouvier JC Varietal and geographic classification of French red wines in terms of pigments and flavonoid compounds. J Sci Food Agric 39— Zand RSR, Jenkins DJA, Diamandis, EP Flavonoids and steroid hormone-dependent cancers.

J Chromatogr B— Duthie GG, Duthie SJ, Kyle JAM Plant polyphenols in cancer and heart disease: Implications as nutritional antioxidants. Nutr Res Rev 79— Chu YH, Chang CL, Hsu HF Flavonoid content of several vegetables and their antioxidant activity.

Arts ICW, Van de Putte B, Hollman PCH Catechin contents of foods commonly consumed in the Netherlands. Fruits, vegetables, staple foods, and processed foods. Hertog MGL, Hollman PCH, Katan MB Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands.

Hertog MGL, Hollman PCH, Van de Putte B Content of potentially anticarcinogenic flavonoids of tea infusions, wines and fruit juices. Tea, wine, fruit juices, and chocolate milk.

Singleton VL, Noble AC Wine flavour and phenolic substances. In: Charalambous G, Katz I edsPhenolic, Sulfur, and Nitrogen Compounds in Food Flavors. Chicago: American Chemical Society, pp 47— Garcia-Viguera C, Bakker J, Bellworthy SJ, Reader HP, Watkins SJ, Bridle P The effect of some processing variables on non-coloured phenolic compounds in port wines.

Z Lebensm Unters Forsch — Gil-Izquierdo A, Gil MI, Ferreres F, Tomás-Barberán FA In vitro availability of flavonoids and other phenolics in orange juice.

Tomás-Barberán FA, Clifford MN Review : Flavanones, chalcones and dihydrochalcones—nature, occurrence and dietary burden. Hertog MG, Hollman PCH, Katan MB Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands.

Cancer 21— Hollman PCH, de Vries JHM, van Leeuwen SDD, Mengelers MJB, Katan MB Absorption of dietary quercetin in healthy ileostomy volunteers. Lee M-J, Wang ZY, Li H Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomark Prev 4: — Hollman PCH, van Trijp JMP, Buysman MNCP, Gaag MS, Mengelers MJB, de Vries JHM, Katan MB Relative bioavailability of the antibioxidant flavonoid quercetin from various foods in Man.

Febs Lett — Ren W, Qian Z, Wang H, Zhu L, Zhang L Flavonoids : Promising anticancer agents. Medicinal Res Rev 23 4 : — Cassidy A, Hanley B, Lamuela-Raventos RM Review : Isoflavones, lignans and stilbenes—origins, metabolism and potential importance to human health.

Lyons-Wall PM, Samman S Flavonoids —dietary perspectives and health benefits. Nutr Soc Aust — Kuhnau J The flavonoids: A class of semi-essential food components: Their role in human nutrition.

Wld Rev Nutri Diet — Chow K, Kramer I All the Tea in China. San Francisco: China Books and Period, Inc. Hara Y Effects of tea polyphenols on cardiovascular diseases. Prev Med Nakagawa K, Ninomiya M, Okubo T, Aoi N, Juneja LR, Kim M, Yamanaka K, Miyazawa T Tea catechin supplementation increases antioxidant capacity and prevents phospholipid hydroperoxidation in plasma of humans.

Van Hof KH, Kivits GAA, Weststrate JA, Tijburg LBM Bioavailability of catechins from tea: The effect of milk. Eur J Clin Nutr — Birt DF, Shull JD, Yaktine A Chemoprevention of cancer. In: Shils ME, Olson JE, Shike M, Ross, AC edsModern Nutrition in Health and Disease Baltimore: Williams and Wilkins.

: Flavonoids and disease prevention

Flavonoids Clin Chem. Article PubMed CAS Google Scholar de Souza dos Santos MC, CFL G, Vaisman M, ACF F, de Carvalho DP. Arch Int Med — Dietary flavonoids intake and risk of type 2 diabetes: a meta-analysis of prospective cohort studies. Dreosti IE, Wargovich MJ, Yang CS Inhibition of carcinogenesis by tea: The evidence from the experimental studies.
You are here Flaavonoids YH, Chang CL, Hsu HF Flavonoid Flavonoids and disease prevention prwvention several vegetables and their antioxidant activity. Life Sci — Close Stay on top of latest health news from Harvard Medical School. Dietary flavonoid intake and risk of stomach and colorectal cancer. Their anti-inflammatory effect could also play a role in this context. Everything You Need to Know.
The thinking on flavonoids - Harvard Health Dang Q, Song W, Xu D, Ma Y, Li F, Zeng J, et al. Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults. Cutler GJ, Nettleton JA, Ross JA, Harnack LJ, Jacobs DR, Scrafford CG, et al. Please sign into your library account to place requests. Darvesh A. The functional mechanism of cate-chins in cell signal transduction is very complex and has not yet been fully explored Mechanisms enforcing the estrogen receptor beta selectivity of botanical estrogens.
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Home News Flavonoids are a flavorful way to boost heart and brain health. Science Photo Library, Getty Images Lea en español What do blueberries, spinach and dark chocolate have in common? If you're not used to eating a lot of produce, you can build it into your diet slowly, she said.

However, she said, "if that's the only way you can get them into your diet, then do it. Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts.

Hou Z, Lambert JD, Chin KV, Yang CS. Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention. Mutat Res. Lambert JD, Yang CS. Mechanisms of cancer prevention by tea constituents. Espley RV, Butts CA, Laing WA, et al. Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice.

Kim MC, Kim SJ, Kim DS, et al. Vanillic acid inhibits inflammatory mediators by suppressing NF-kappaB in lipopolysaccharide-stimulated mouse peritoneal macrophages. Immunopharmacol Immunotoxicol. Lee SG, Kim B, Yang Y, et al.

Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-kappaB independent of NRF2-mediated mechanism. J Nutr Biochem.

Mauray A, Felgines C, Morand C, Mazur A, Scalbert A, Milenkovic D. Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice.

Nutr Metab Cardiovasc Dis. Wang D, Wei X, Yan X, Jin T, Ling W. Protocatechuic acid, a metabolite of anthocyanins, inhibits monocyte adhesion and reduces atherosclerosis in apolipoprotein E-deficient mice. Edirisinghe I, Banaszewski K, Cappozzo J, McCarthy D, Burton-Freeman BM.

Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase eNOS in vitro in human endothelial cells. Hidalgo M, Martin-Santamaria S, Recio I, et al. Genes Nutr. Chen XQ, Wang XB, Guan RF, et al. Blood anticoagulation and antiplatelet activity of green tea - -epigallocatechin EGC in mice.

Ahmad A, Khan RM, Alkharfy KM. Effects of selected bioactive natural products on the vascular endothelium. J Cardiovasc Pharmacol. Hanhineva K, Torronen R, Bondia-Pons I, et al. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci. Babu PV, Liu D, Gilbert ER.

Recent advances in understanding the anti-diabetic actions of dietary flavonoids. Delgado ME, Haza AI, Arranz N, Garcia A, Morales P. Erba D, Casiraghi MC, Martinez-Conesa C, Goi G, Massaccesi L.

Isoflavone supplementation reduces DNA oxidative damage and increases O-β-N-acetyl-D-glucosaminidase activity in healthy women. Nutr Res. Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

Schwarz D, Kisselev P, Roots I. CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin. Eur J Cancer. Suh Y, Afaq F, Johnson JJ, Mukhtar H. Ravishankar D, Watson KA, Boateng SY, Green RJ, Greco F, Osborn HM. Exploring quercetin and luteolin derivatives as antiangiogenic agents.

Eur J Med Chem. Santos BL, Oliveira MN, Coelho PC, et al. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. Chem Biol Interact. Sokolov AN, Pavlova MA, Klosterhalfen S, Enck P.

Chocolate and the brain: neurobiological impact of cocoa flavanols on cognition and behavior. Neurosci Biobehav Rev. Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP.

The neuroprotective potential of flavonoids: a multiplicity of effects. Wang X, Ouyang YY, Liu J, Zhao G. Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies. Br J Nutr. Wang ZM, Zhao D, Nie ZL, et al.

Flavonol intake and stroke risk: a meta-analysis of cohort studies. Jacques PF, Cassidy A, Rogers G, Peterson JJ, Dwyer JT. Dietary flavonoid intakes and CVD incidence in the Framingham Offspring Cohort. US Department of Agriculture.

USDA Database for the Proanthocyanidin Content of Selected Foods. August, USDA Database for the Isoflavone Content of Selected Foods, release 2. September USDA Database for the Flavonoid Content of Selected Foods, release 3.

May Vogiatzoglou A, Mulligan AA, Bhaniani A, et al. Associations between flavanol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer EPIC-Norfolk.

Cassidy A, Rogers G, Peterson JJ, Dwyer JT, Lin H, Jacques PF. Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults.

Grassi D, Desideri G, Ferri C. Protective effects of dark chocolate on endothelial function and diabetes. Curr Opin Clin Nutr Metab Care. Sansone R, Rodriguez-Mateos A, Heuel J, et al. Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study.

Basu A, Fu DX, Wilkinson M, et al. Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome. Kelley DS, Rasooly R, Jacob RA, Kader AA, Mackey BE.

Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women. Moazen S, Amani R, Homayouni Rad A, Shahbazian H, Ahmadi K, Taha Jalali M.

Effects of freeze-dried strawberry supplementation on metabolic biomarkers of atherosclerosis in subjects with type 2 diabetes: a randomized double-blind controlled trial. Ann Nutr Metab. Edirisinghe I, Banaszewski K, Cappozzo J, et al. Strawberry anthocyanin and its association with postprandial inflammation and insulin.

Karlsen A, Retterstol L, Laake P, et al. Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults.

Basu A, Lyons TJ. Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives. Zhu Y, Ling W, Guo H, et al. Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial.

Qin Y, Xia M, Ma J, et al. Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects.

Zhu Y, Huang X, Zhang Y, et al. Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia.

J Clin Endocrinol Metab. Curtis PJ, Kroon PA, Hollands WJ, et al. Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks.

Grassi D, Desideri G, Di Giosia P, et al. Tea, flavonoids, and cardiovascular health: endothelial protection. Forstermann U, Sessa WC.

Nitric oxide synthases: regulation and function. Ras RT, Streppel MT, Draijer R, Zock PL. Flow-mediated dilation and cardiovascular risk prediction: a systematic review with meta-analysis. Int J Cardiol. Liu Y, Li D, Zhang Y, Sun R, Xia M.

Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Am J Physiol Endocrinol Metab.

Zhu Y, Xia M, Yang Y, et al. Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clin Chem. Ras RT, Zock PL, Draijer R. Tea consumption enhances endothelial-dependent vasodilation; a meta-analysis.

PLoS One. Hooper L, Kay C, Abdelhamid A, et al. Effects of chocolate, cocoa, and flavanols on cardiovascular health: a systematic review and meta-analysis of randomized trials.

Grassi D, Necozione S, Lippi C, et al. Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Grassi D, Desideri G, Necozione S, et al. Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia.

Davison K, Coates AM, Buckley JD, Howe PR. Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects. Int J Obes Lond. West SG, McIntyre MD, Piotrowski MJ, et al.

Effects of dark chocolate and cocoa consumption on endothelial function and arterial stiffness in overweight adults.

Flammer AJ, Sudano I, Wolfrum M, et al. Cardiovascular effects of flavanol-rich chocolate in patients with heart failure. Schroeter H, Heiss C, Balzer J, et al. Proc Natl Acad Sci U S A. Gomez-Guzman M, Jimenez R, Sanchez M, et al.

Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension.

Bachmair EM, Ostertag LM, Zhang X, de Roos B. Dietary manipulation of platelet function. Pharmacol Ther. Pearson DA, Paglieroni TG, Rein D, et al. The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function.

Thromb Res. Ried K, Sullivan TR, Fakler P, Frank OR, Stocks NP. Effect of cocoa on blood pressure. Cochrane Database Syst Rev. Khalesi S, Sun J, Buys N, Jamshidi A, Nikbakht-Nasrabadi E, Khosravi-Boroujeni H.

Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials. Guerrero L, Castillo J, Quinones M, et al. Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies.

Egert S, Bosy-Westphal A, Seiberl J, et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study.

Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. Zahedi M, Ghiasvand R, Feizi A, Asgari G, Darvish L.

Does Quercetin Improve Cardiovascular Risk factors and Inflammatory Biomarkers in Women with Type 2 Diabetes: A Double-blind Randomized Controlled Clinical Trial.

Int J Prev Med. Brull V, Burak C, Stoffel-Wagner B, et al. Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with pre- hypertension: a randomised double-blinded placebo-controlled cross-over trial.

Zamora-Ros R, Forouhi NG, Sharp SJ, et al. The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study. Diabetes Care. Dietary intakes of individual flavanols and flavonols are inversely associated with incident type 2 diabetes in European populations.

Wang X, Tian J, Jiang J, et al. Effects of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of type 2 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials.

J Hum Nutr Diet. Liu K, Zhou R, Wang B, et al. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials.

Zheng XX, Xu YL, Li SH, Hui R, Wu YJ, Huang XH. Effects of green tea catechins with or without caffeine on glycemic control in adults: a meta-analysis of randomized controlled trials. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.

Curtis PJ, Sampson M, Potter J, Dhatariya K, Kroon PA, Cassidy A. Chronic ingestion of flavanols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated year CVD risk in medicated postmenopausal women with type 2 diabetes: a 1-year, double-blind, randomized, controlled trial.

Wedick NM, Pan A, Cassidy A, et al. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Hokayem M, Blond E, Vidal H, et al.

Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients.

Soltani R, Gorji A, Asgary S, Sarrafzadegan N, Siavash M. Evaluation of the Effects of Cornus mas L. Fruit Extract on Glycemic Control and Insulin Level in Type 2 Diabetic Adult Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Evid Based Complement Alternat Med.

Li D, Zhang Y, Liu Y, Sun R, Xia M. Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients.

Yang CS, Yang GY, Landau JM, Kim S, Liao J. Tea and tea polyphenols inhibit cell hyperproliferation, lung tumorigenesis, and tumor progression. Exp Lung Res. Balasubramanian S, Govindasamy S.

Inhibitory effect of dietary flavonol quercetin on 7,dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Li ZG, Shimada Y, Sato F, et al.

Inhibitory effects of epigallocatechingallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F rats. Int J Oncol. Yamane T, Nakatani H, Kikuoka N, et al.

Inhibitory effects and toxicity of green tea polyphenols for gastrointestinal carcinogenesis. Guo JY, Li X, Browning JD, Jr. Dietary soy isoflavones and estrone protect ovariectomized ERαKO and wild-type mice from carcinogen-induced colon cancer.

Huang MT, Xie JG, Wang ZY, et al. Effects of tea, decaffeinated tea, and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: demonstration of caffeine as a biologically important constituent of tea.

Gupta S, Hastak K, Ahmad N, Lewin JS, Mukhtar H. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Haddad AQ, Venkateswaran V, Viswanathan L, Teahan SJ, Fleshner NE, Klotz LH.

Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines. Prostate Cancer Prostatic Dis. Yamagishi M, Natsume M, Osakabe N, et al. Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats.

Cancer Lett. Romagnolo DF, Selmin OI. Flavonoids and cancer prevention: a review of the evidence. J Nutr Gerontol Geriatr. Woo HD, Kim J. Dietary flavonoid intake and risk of stomach and colorectal cancer. World J Gastroenterol.

Nimptsch K, Zhang X, Cassidy A, et al. Habitual intake of flavonoid subclasses and risk of colorectal cancer in 2 large prospective cohorts. Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis. Tang NP, Zhou B, Wang B, Yu RB, Ma J. Flavonoids intake and risk of lung cancer: a meta-analysis.

Jpn J Clin Oncol. Ollberding NJ, Lim U, Wilkens LR, et al. Legume, soy, tofu, and isoflavone intake and endometrial cancer risk in postmenopausal women in the multiethnic cohort study.

J Natl Cancer Inst. Bandera EV, King M, Chandran U, Paddock LE, Rodriguez-Rodriguez L, Olson SH. Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study.

BMC Womens Health. Cassidy A, Huang T, Rice MS, Rimm EB, Tworoger SS. Intake of dietary flavonoids and risk of epithelial ovarian cancer. Gates MA, Vitonis AF, Tworoger SS, et al. Flavonoid intake and ovarian cancer risk in a population-based case-control study. Int J Cancer.

Rossi M, Negri E, Lagiou P, et al. Flavonoids and ovarian cancer risk: A case-control study in Italy. Ko KP. Isoflavones: chemistry, analysis, functions and effects on health and cancer. Asian Pac J Cancer Prev. Dong JY, Qin LQ. Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies.

Breast Cancer Res Treat. Iwasaki M, Hamada GS, Nishimoto IN, et al. A variety of fruits and vegetables contain flavonoids. Some of the highest amounts are in berries, apples, citrus fruit oranges, lemons , grapes, spinach, legumes, kale, broccoli, soybeans, onions, tea, cocoa, and wine.

See "Flavonoids and food. Researchers believe flavonoids may help the brain in several ways. For instance, studies suggest they reduce cell-damaging free radicals and soothe inflammation. Some early-stage animal studies have shown that flavonoids can block beta-amyloid plaque buildup in the brain, a trademark of Alzheimer's.

Flavonoids also may enhance brain blood flow. There are six subclasses of flavonoids, which are abundant in most plant foods. tea black, white, green, oolong , cocoa-based products, grapes, berries, apples, red wine. Large human studies of flavonoids are still in their early phases, but initial findings show promise.

One of the most substantial to date was a recent study linking high flavonoid intake and a lower risk of Alzheimer's and related dementias conditions with symptoms similar to Alzheimer's.

The results were published online April 22, , by The American Journal of Clinical Nutrition. Using data from the Framingham Heart Study, researchers looked at the dietary habits of almost 3, people, average age 59, without any signs of dementia.

Over 20 years, people with the highest daily intake of flavonoids about milligrams had a lower risk of developing Alzheimer's or a related dementia than those who ate the smallest amounts about milligrams. Still, the link between flavonoids and brain health might be a matter of coincidence.

So, to protect your brain from dementia, should you load up your plate with as many flavonoid-rich foods as possible? Not really, according to Dr. She says that the standard advice to follow a plant-based diet as much as possible still applies, and eating a variety of colors is a good idea.

How much is enough? Yeh says although there is still no definite recommended daily intake for flavonoids, aiming for the suggested five to nine servings of fruits and vegetables a day is a good goal.

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In this Special Health Report, Harvard Medical School doctors share a six-step program that can yield important and lasting results. From simple and specific changes in eating to ways to challenge your brain, this is guidance that will pay dividends for you and your future. Thanks for visiting.

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Can flavonoids reduce risk of heart disease? - Dr. Sreekanth B Shetty

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