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Turmeric curcumin research

Turmeric curcumin research

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Turmeric for Inflammation: How Much is Enough? Turmeric is a Turmeric curcumin research derived from the Tyrmeric of the tropical plant Curcuma longa Linn, which is a rdsearch of Carbohydrate metabolism and fructose metabolism ginger reeearch Zingiberaceae. Turmetic are horizontal Boost energy for increased productivity stems Turmeric curcumin research send out shoots, as well as roots. The bright yellow-orange color of turmeric comes mainly from fat-soluble, polyphenolic pigments known as curcuminoids. Curcumin, the principal curcuminoid found in turmeric, is generally considered its most active constituent 1. Other curcuminoids found in turmeric include demethoxycurcumin and bisdemethoxycurcumin Figure 1. In addition to its use as a spice and pigment, turmeric has been used in India for medicinal purposes for centuries 2.

Turmeric curcumin research -

Most are based on the curcumin turmeric contains, which has been shown to be a potent anti-inflammatory and antioxidant. This is where it gets more complicated. The scientific studies that have made positive health associations use either pure curcumin or turmeric extract that has been designed to contain mostly curcumin.

The doses of curcumin required to give benefit are very high — typically about 1,mg a day. So despite what manufacturers might claim, consuming turmeric shots and lattes or adding a little extra spice to your meals will not come close to reaching the necessary dose.

Some turmeric products have even been found to be contaminated with heavy metals such as lead , which can have adverse effects on your health. The most convincing evidence so far relates to its ability to relieve joint pain in people with osteoarthritis, an area of medicine where there is a huge unmet need owing to the limitations of non-steroidal anti-inflammatory drugs NSAIDs.

But this is just one area of investigation. There are 70 clinical trials around the world that are either active or seeking patients, and are looking at the potential of curcumin to treat chronic kidney disease, cognitive decline, irritable bowel syndrome IBS , macular degeneration, and even to slow down the progression of various forms of cancer.

In the mid s, Jack Arbiser and Nancy DeMore were young researchers at Harvard Medical School exploring new treatment options for cancer, when they came across some research suggesting that curcumin could inhibit the growth of different types of cancer cells in a test tube.

Intrigued by this, they went on to find that curcumin could prevent the formation of new blood vessels , a process called angiogenesis, which all tumours require to sustain themselves.

There have since been several studies using curcumin in clinical trials in patients with pancreatic cancer, breast cancer, and multiple myeloma showing that there is some biologic effect. However, when scientists moved from testing curcumin in the lab to testing it on humans, there was a catch — one that has dogged curcumin ever since.

The compound has notoriously poor bioavailability — the rate at which the body absorbs a substance — making it nearly impossible to get sufficiently high concentrations of curcumin into the blood through oral supplementation alone.

This, along with the commercial difficulties of patenting natural products, meant that scientific interest in curcumin soon waned, and would remain in the doldrums for more than a decade. But in recent years, advances in drug delivery techniques have renewed interest in curcumin.

Nanoparticle systems are being explored as ways of potentially getting high doses of curcumin to tumours. Some research has shown that combining curcumin with piperine — a compound found in black pepper — can enhance its absorption into the blood , although it still remains to be proven whether this can help yield benefit in humans.

While there are now a whole variety of off-the-shelf supplements that combine curcumin and piperine, there are still challenges for scientists looking to use it medically.

One of these is that piperine has been shown to inhibit a variety of enzymes that aid in metabolising drugs, and it remains to be seen whether this could cause an increased risk of side-effects in patients also taking prescription medicines.

This has been accelerated by a drive for more natural alternatives to painkillers, but also by the fact that in the world of sport, curcumin has gained a reputation as an aid to muscle rehabilitation. Scientists at Northumbria University are planning a clinical trial to study this, while in the US, Paultre is already witnessing the rise of curcumin as a sports supplement.

We tend to avoid chronic NSAID use in athletes due to side-effects. The evidence seems to be positive, but once again there is still work to be done. DeMore, now a professor of surgery at the Medical University of South Carolina, has returned to studying curcumin after a near year gap, launching a clinical trial to see whether breast cancer patients taking a formulation of curcumin specially designed to enhance its absorption into the blood experience a decrease in tumour proliferation.

At the same time, oncologists at the University of Rochester Medical Center in New York state are running a trial to see whether curcumin supplemented with piperine can halt disease progression in patients with low-grade prostate cancer, and prevent them from requiring more aggressive treatment.

In both cases, scientists are keen to emphasise that these trials are very much in the exploratory stage, and even if they produce positive results, far more proof will be needed before curcumin can be officially recommended for cancer patients. When there is evidence, it usually demonstrates no consistent or clear benefit.

A study published in BMC suggests that curcumin, a naturally occurring substance found in a common spice, might help ease osteoarthritis pain. In the study, researchers enrolled people with symptoms of knee osteoarthritis. Their symptoms were at least moderately severe and required treatment with a nonsteroidal anti-inflammatory drug NSAID.

For one month, they were given the NSAID diclofenac 50 mg, twice daily or curcumin mg, three times daily. Why curcumin? Its use has been advocated for cardiovascular health, arthritis, and a host of other conditions. However, well-designed studies of its health benefits are limited.

Not so fast.

W hile Kamal Patel curcuumin probing through the reams of user data on curcumiin. Besides Turmeruc use Turmdric pill supplements, curcumin is increasingly being incorporated tesearch cosmetic products Delicious diabetic dishes claim to help treat acne and eczema, Turmeic dry skin, Pancreatic polyp even slow Health risks of extreme high-protein diets the Energy metabolism and sports performance reesearch. The Rexearch rhizomes of Boost energy for increased productivity turmeric plant are commonly Boost energy for increased productivity durcumin curry powder, but turmeric has also been part of Ayurvedic medicine — a traditional Indian system of treatment — for centuries, and at some point in the last decade turmeric worked its way out of the spice cupboard and took its place at the forefront of the western wellness industry. It has been subject to all kinds of wild and wonderful health claims, including the ability to relieve allergies, prevent cancer, improve heart health, reverse cognitive decline, cure depression and increase longevity. As with any dietary supplement, separating the hype and the truth is not straightforward, since not all the claims about turmeric are complete hyperbole. Most are based on the curcumin turmeric contains, which has been shown to be a potent anti-inflammatory and antioxidant. This is where it gets more complicated. Turmeric curcumin research

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