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Medicinal plants for diabetes

Medicinal plants for diabetes

;lants and Pancreatic cyst Medicinal plants for diabetes in the information provided here diaebtes advertisements of third-party products available on the website. Plantx in Immune support capsules of Mrdicinal Risk Selenium for mobile testing Among US Adults with Type 2 Diabetes from to Comparison by Prevalent Cardiovascular Disease Status. Read more about the benefits of aloe vera for skin and hair. It increases the sensitivity of the body to insulin and helps in increasing insulin secretion. central India and Sri Lanka.

Medicinal plants for diabetes -

Silymarin, the extract from milk thistle that scientists have paid most attention to, is a compound with antioxidant and anti-inflammatory properties.

These may make milk thistle a useful herb for people with diabetes. Many results of investigations into the effects of silymarin have been promising, but not promising enough for experts to recommend the herb or its extract alone for diabetes care, according to one review from The authors of research from found modest evidence that milk thistle might help lower glucose levels in people with diabetes.

They also warned that, while people generally tolerate the herb well, milk thistle could lead to:. Fenugreek is a seed that may help lower blood sugar levels. It contains fibers and chemicals that help slow down the digestion of carbohydrates and sugar. There is also some evidence that the seed may help delay or prevent the onset of type 2 diabetes.

Findings of a three-year investigation from noted that people with prediabetes were less likely to receive a diagnosis of type 2 diabetes while taking powdered fenugreek seed. The study involved 66 people with diabetes who took 5 grams of the seed with milliliters of water twice a day before meals and 74 healthy participants who did not take it.

The researchers concluded that taking the seed preparation led to a reduction in blood sugar resulting from increased insulin levels. They also found that the preparation led to reduced cholesterol levels. Gymnema sylvestre is an herb that comes from India. One review of cell and rodent studies reported gymnema could:.

One human study found those who took a mint containing gymnema reported a lesser desire for sweet treats such as chocolate. However, it did not include people with diabetes as participants. Still, it may help people with diabetes who would like help reducing their sugar intake.

Using either the ground leaf or leaf extract may be beneficial, but a person should speak with a healthcare professional beforehand. Ginger is another herb that people have used for thousands of years in traditional medicines. People often use ginger to help treat digestive and inflammatory issues.

In , a review found that it could also help treat diabetes. The researchers concluded that ginger lowered blood sugar levels but not blood insulin levels. As a result, they suggested that ginger might reduce insulin resistance in people with type 2 diabetes. However, the way that ginger accomplished this was unclear, and the team called for more research to confirm the findings.

A small study found that ginger could reduce both fasting blood glucose and HbA1c levels. A person should always work with a healthcare professional before taking any new herb or supplement. They may suggest starting with a lower dosage and gradually increasing it until there are noticeable satisfactory effects.

Some herbs can interact with medications that do the same job, such as blood thinners and high blood pressure medications.

It is essential to be aware of any interactions before trying a new supplement. The FDA does not monitor herbs and supplements, so different products may contain different herbs and fillers.

Also, packaging may recommend potentially harmful dosages, and products can be contaminated, for example, with pesticides. In addition, herbs and supplements are complementary treatment options and should not replace medications. People can discover more resources for living with type 2 diabetes by downloading the free Bezzy T2D app for iPhone or Android.

It provides access to expert content on type 2 diabetes, as well as peer support through one-on-one conversations and live group discussions. New guidelines from the American College of Physicians recommend that clinicians aim for moderate blood sugar levels in patients with type 2 diabetes….

Researchers suggest that targeting the gut microbiota could be a potential strategy for the prevention and treatment of type 1 diabetes. People with diabetes can use various strategies to lower their blood sugar levels.

The options include lifestyle and dietary changes and natural…. Not just does rosemary promote weight loss but it also balances blood sugar levels. Rosemary is also responsible for reducing bad cholesterol LDL and increasing good cholesterol HDL. As part of oriental medicine, ginseng has been in use for many centuries.

It has superlative immune-boosting properties and is anti-diabetic. Ginseng reduces the rate of absorption of carbs in the body. Ginseng also accelerates the production of insulin by the pancreas. Research has shown that sage reduces blood sugar levels to a significant amount, more so when consumed on an empty stomach.

Adding sage to the diet increases the secretion of insulin and helps manage diabetes better. It is best consumed in the form of tea. This herb has been part of ayurvedic cures for diabetes in India since time immemorial.

It has gymnemic acids which neutralize the taste buds on the tongue towards sweet things. This helps the person to control sugar cravings. The herb also helps in the utilisation of excess glucose in the blood. This herb has a two-pronged effect on high blood sugar. It increases the activity in the pancreas to make more insulin and reduces blood sugar levels by inhibiting cravings for sweets.

The glucose in the cells gets mobilised due to specific components present in oregano. Apart from boosting immune health, it reduces carbohydrate formation in the body.

The fleshy plant forms an essential part of alternative medicine in India, Mexico, Australia and South America. It reduces inflammation in the body and treats indigestion. Inflammation in the body is responsible for many chronic lifestyle diseases like diabetes.

Read more about the benefits of aloe vera for skin and hair. We conducted a narrative synthesis of the other results.

In this analysis we only included remedies for which both measures were reported. Where a remedy had differing results from several reviews, we took the rank of the best result for each of HbA1c and FPG.

Our initial search identified 2, articles after removing duplicates Figure 1. Forty-nine full texts were screened and of these, 25 met all our inclusion criteria Davis and Yokoyama, ; Kim et al. The commonest reason for exclusion was that the review did not attempt a quantitative meta-analysis of randomised controlled trials.

One of the meta-analyses was excluded because it had incorrectly reported underlying data from included studies and its results were inaccurate Gong et al. There were reviews on 18 different medicinal plants Table 1.

Some herbal remedies had more than one review: cinnamon Davis and Yokoyama, ; Leach and Kumar, ; Allen et al. Three reviews evaluated the effect of a standard traditional Chinese herbal formula which contained a mixture of several herbs. Gegen formulae contained Pueraria lobata root as their main constituent alongside other ingredients such as Salvia miltiorrhiza root, liquorice root and Dioscorea opposita rhizome Yang et al.

Jinqi Jiangtang contains Astragalus membranaceus root, Coptis spp rhizome and lonicera japonica Gao et al. Tianmai Xiaoke contains Trichosanthes root, Ophiopogon japonicus root, Schisandra chinensis fruit and chromium picolinate Gu et al. Some reviews studied the effect of specific plant products which are also used as foods: olive oil Schwingshackl et al.

All the reviews included mainly clinical trials in patients with T2DM see Table 1 but four also included a few trials in patients with pre-diabetes. One included a single trial in patients with T1DM, but its results were presented separately and excluded from this review. Five reviews included only trials of patients with diet-controlled diabetes, not taking any conventional antidiabetic medications.

Fourteen reviews included trials in which both intervention and control groups received concomitant conventional treatment with oral hypoglycaemic agents OHA. Five reviews did not specify whether concomitant treatment was given. In three reviews, some studies gave a conventional OHA to the control group only, not to the treatment group Ooi et al.

Duration of follow-up was most often 4—12 weeks, but there was a wide range with a few included studies following up for as little as 1 week or for as long as 4 years. All the reviews included randomised controlled trials but two also included a few non-randomised controlled trials.

The reviews included a median of eight trials and participants but the smallest included only a single trial and the largest review included 25 studies participants. The AMSTAR-2 scores for each study are shown in Supplementary Material.

Several quality issues were identified with the other reviews. Most did not report that there was a pre-established published protocol.

Most did not have a fully comprehensive search strategy including the grey literature. Most did not list all excluded studies and most did not report on the sources of funding for the studies included in the review.

Seven did not adequately investigate publication bias. Six did not report conflicts of interest, including the review on Psyllium which was led by a company marketing a Psyllium product Gibb et al.

Twenty-one studies on 16 remedies attempted to conduct a meta-analysis quantifying the reduction in HbA1c Figure 2. The most effective remedy appeared to be Aloe vera freshly extracted juice Suksomboon et al.

Psyllium fibre Gibb et al. Nigella sativa seeds Daryabeygi-Khotbehsara et al. Nettle Urtica dioica appeared to lead to a clinically significant reduction but this was not statistically significant because of very wide confidence intervals Ziaei et al. FIGURE 2. The red dotted line indicates the threshold for a clinically significant effect reduction by 0.

Several remedies produced a statistically significant reduction in HbA1c but the standard mean difference fell below the pre-determined threshold of 0. These were the patent traditional Chinese formula Tianmai Xiaoke Gu et al.

Momordica charantia was studied by two reviews which came to differing conclusions; an early Cochrane review found only a single small RCT with 40 participants, which concluded that Karela dried powder in capsules appeared to be ineffective Ooi et al.

However, a more recent and comprehensive review including five RCTs participants found that there was a statistically significant reduction in HbA1c by 0. Similarly, the four reviews on cinnamon which reported HbA1c came to slightly different conclusions; only one found a statistically significant reduction and none of them reported a clinically significant reduction.

Two meta-analyses of ginseng Kim et al. Twenty-five reviews meta-analysed the reduction in FPG Figure 3. All the remedies which produced clinically significant reductions in HbA1c also produced clinically and statistically significant reductions in FPG, with the exception of Astragalus membranaceus , which reduced FPG slightly less than the predetermined clinically significant threshold of 0.

Nettle Urtica dioica , Momordica charantia and sweet potato also all produced clinically significant reductions in FPG. FIGURE 3. Other reviews also included patients with T1DM Leach and Kumar, or pre-diabetes Davis and Yokoyama, ; Deyno et al.

For several remedies, there was a wide degree of uncertainty regarding their effectiveness in reducing FPG. Dragon fruit appeared to have a large effect but this was not statistically significant as there were very wide confidence intervals Poolsup et al. There was also a large degree of uncertainty about the effect of Mulberry leaf—there was a wide confidence interval, and a second trial not included in the meta-analysis reported that it was more effective than glibenclamide Shin et al.

Of the two reviews on Ginseng, that by Kim et al. Another meta-analysis did report a significant reduction in FPG but also included pre-diabetic patients Gui et al. It can be stated with some certainty that ginger and tea Camellia sinensis extracts were ineffective for reducing FPG. Neither had a significant effect, and confidence intervals were tight.

None of the included reviews reported any serious adverse events. In most cases there was no significant difference in the incidence of adverse events between the treatment and control groups Table 2.

Mild gastrointestinal symptoms such as diarrhoea, vomiting and abdominal discomfort were reported in a few cases for certain herbal remedies, in particular Momordica charantia three participants and Fenugreek seeds three participants.

There was no specific mention of drug interactions although 14 of the reviews included trials in which the herbal medicine was given in addition to conventional oral hypoglycaemic agents. Only three of these reviews mentioned cases of hypoglycaemia, including only one reported case of a hypoglycaemic seizure in a clinical trial of cinnamon given to adolescent T1DM patients on insulin Leach and Kumar, There have been many RCTs on different phytomedicines and herbal medicines for T2DM, and 25 published meta-analyses on 18 different medicinal plants.

Of these, seven have a clinically and statistically significant effect on HbA1c and 12 on FPG Figures 2 , 3. The most effective on both measures appear to be Aloe vera , Psyllium fibre, Fenugreek seeds, Nigella sativa seeds, and the complex traditional Chinese formula Jinqi Jiangtang.

Tea and tea extracts were ineffective. The 12 other remedies showed some degree of effectiveness on either HbA1c or FPG, but in some cases with a wide degree of uncertainty. All of the medicinal plants evaluated in this review appeared to be safe, with no serious adverse effects reported.

However, some were associated with minor side-effects, in particular gastrointestinal disturbances. This the first study to provide a systematic, evidence-based overview of meta-analyses of the effectiveness of medicinal plants for glycaemic control in type 2 diabetes.

Our systematic approach with broad search terms ensured that we probably found most relevant articles. One limitation is that we did not have the time to search the grey literature or databases in foreign languages such as Chinese. Another limitation is that we were not able to include medicinal plants for which there had been no systematic review with a meta-analysis.

For example there was a systematic review of the Ayurvedic remedy Gymnema sylvestre Leach, but this found no clinical trials which met its inclusion criteria.

It is also likely that there are other potentially effective medicinal plants which have been evaluated in RCTs but not reviewed in a meta-analysis, and others which have not been evaluated in an RCT although lower-level evidence suggests they could be effective Sissoko et al.

Our results are also limited by the quality of the trials included in the meta-analyses. Although most only included RCTs, in some cases the preparation or dosage of the phytomedicine may have been suboptimal; in some reviews both herbal remedies and standardised phytomedicines were included.

The clinical condition of the patients may have been different between trials where patients were taking concomitant oral antidiabetics and those who were purely diet controlled.

In some trials, the duration of follow-up was insufficient to measure the effect on HbA1c, which should be measured at least 3 months after the start of treatment to reveal its full effect. Follow-up duration was generally short: only three reviews included studies with follow-up of 1 year or more, so there is little information on long-term adherence to herbal remedies.

The effect of the most promising medicinal plants was similar to that of standard oral hypoglycaemic agents. In a meta-analysis, metformin monotherapy lowered HbA1c by 1. Metformin added to oral therapy lowered HbA1c by 0. Several mechanisms of action explain the effect of medicinal plants.

Firstly, many plant products contain gel-forming fibres which delay gastric emptying and interfere with glucose absorption from the intestines—for example Aloe vera Suksomboon et al.

Secondly, some medicinal plants contain substances which inhibit enzymes involved in digestion of carbohydrates eg α-amylase, α-glucosidase , such as nettle Ziaei et al. Third, others stimulate release of insulin; these include Fenugreek seeds Neelakantan et al. Fourth, some medicinal plants inhibit gluconeogenesis, including Nigella sativa Daryabeygi-Khotbehsara et al.

Fifth, some, such as nettle Ziaei et al. Dietary and lifestyle advice for patients with diabetes rarely includes information on natural remedies, herbs and spices that can help with glycaemic control.

The results presented here can guide patients who wish to try herbal supplements and foods as part of their self-care and diet, and clinicians who wish to advise them.

Several of the remedies tested are effective and safe. Many of these herbs and spices with clinically assessed hypoglycemic properties are common food products, and as such generally considered very safe.

Some can easily be incorporated into the diet—for example in some studies fenugreek seed powder was mixed with flour for baking chapatis, to reach a total daily dose of g Neelakantan et al. Other herbs can easily be purchased without a prescription for example Aloe vera , Psyllium fibre, and Nigella seeds.

However, it would be necessary to ensure that an adequate dosage is taken of the most effective preparations. The most effective preparation of Aloe vera appeared to be freshly extracted juice, followed by powdered gel in capsules Suksomboon et al.

In the case of Psyllium, the most effective preparation appeared to be the seed husk of Plantago ovata Forssk Ziai et al. For Nigella sativa , the seed powder at a dose of 2 g daily was more effective than the oil Daryabeygi-Khotbehsara et al.

It is equally important to inform patients and clinicians about remedies which appear to be ineffective—such as tea extracts—and those for which there is insufficient evidence of effectiveness—for example cinnamon and ginseng.

Firstly, some of the meta-analyses were performed more than 5 years ago and need to be updated to include the most recent trials. Some reviews were not performed to the highest standards and could be improved. In particular we recommend that the meta-analysis on Fenugreek should be updated because this appears to be one of the most effective remedies but the systematic review was done in Neelakantan et al.

A later systematic review suggested an even greater effect but incorrectly reported some of the underlying data Gong et al. It would also be useful to perform a network meta-analysis to estimate the relative effects between the different herbal interventions. Secondly, it would be interesting to evaluate the impact on glycaemic control of including information on effective medicinal plants and herbal remedies within dietary and lifestyle advice for patients with type 2 diabetes.

This information would need to include clear instructions on the most effective preparations and dosages, and to warn patients about potential side-effects. Thirdly, this review found a large number of potentially effective medicinal plants for which there is insufficient evidence of effectiveness.

For example, Nettle Urtica dioica appears to have a significant effect on HbA1c and FPG Ziaei et al. Larger trials are needed to provide a more precise estimate of efficacy. Although it appears effective, the results on Psyllium were at high risk of bias because the review was undertaken by a company selling it—a higher quality review, with low risk of bias, would be helpful.

In some studies, cinnamon appears to significantly reduce FPG, but not HbA1c. However, there is a wide variety of cinnamon species, preparations and doses—it is likely that some are more effective than others.

Further research is needed to identify the most effective preparations and dosages, and to conduct high-quality clinical trials of these. Fourth, for the majority of the 1, remedies which have been traditionally used in the treatment of diabetes Simmonds et al.

Some of these have preliminary evidence of effectiveness, for example on post-prandial glucose; these include the Ayurvedic remedy Gymnema sylvestre Leach, and the West African tree Moringa oleifera Sissoko et al.

It is important to conduct high-quality clinical trials of these at low risk of bias, using a standardised, replicable dosage and preparation, and measuring HbA1c after at least 12 weeks. Several medicinal plants have the potential to lower HbA1c and could be effective as an adjunct to other lifestyle measures and current treatment, in particular Aloe vera, Psyllium fibre, Fenugreek seeds, Nigella sativa seeds and the Chinese formula Jinqi Jiangtang.

It is also clear that tea and tea extracts are ineffective. Rigorous trials with at least 3 months follow-up are needed to ascertain the safety and effectiveness of promising plant-based preparations on diabetes. Practical information on safe plant-based preparations with hypo-glycaemic effects should be made widely available to clinicians and patients with diabetes.

MW, ML, and BG conceived and designed the study. CE and MA-A conducted the literature searches, screening, quality appraisal and data extraction.

Aims: To ppants the effectiveness of medicinal plants plantz glycaemic Immune support capsules in Type 2 Ofr T2DM. Methods: MEDLINE, EMBASE, CINAHL and Natural weight loss for seniors Central Medicinal plants for diabetes searched fkr October Results: Twenty five meta-analyses reported the effects of 18 plant-based remedies. Aloe vera leaf gel, Psyllium fibre and Fenugreek seeds had the largest effects on HbA1c: mean difference —0. Four other remedies reduced HbA1c by at least 0. No serious adverse effects were reported. Several other herbal medicines significantly reduced FPG. Lifestyle strategies and plangs are the main ways to fod type 2 diabetes. But, some plant remedies, herbs, Immune support capsules supplements Medjcinal such as aloe Diaberes and bitter Fall-related injury prevention — may also help. In diabetesImmune support capsules body either plats Medicinal plants for diabetes produce plnts insulin Meidcinal produces insulin that it does not use effectively. Herbs and supplements cannot cure diabetes and cannot be a standalone treatment. However, some, combined with conventional treatment, may relieve diabetes symptoms and reduce the risk of complications. According to the American Diabetes Association ADA Standards of Medical Care in Diabetesthere is no clear evidence of herbs or supplements benefitting people with diabetes without additional conditions. Additionally, the Food and Drug Administration FDA does not regulate herbs and supplements, so some products may contain different herbs and fillers. Medicinal plants for diabetes


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